Sense making occupies a peculiar and generative position within the depth-psychology corpus: it appears simultaneously as a biological imperative, a relational achievement, a cognitive operation, and a spiritual aspiration. The most theoretically rigorous treatment emerges from the enactivist tradition, where Evan Thompson, drawing on Varela, establishes sense making as the constitutive activity of living systems — not merely a cognitive gloss upon pre-given data, but the very manner in which autopoietic organisms enact a world of significance from their autonomous organisation. Here sense making is inseparable from identity: to be alive is to make sense. A sharply contrasting register appears in the bereavement literature gathered under Neimeyer’s editorship, where sense making denotes the hermeneutic labour of survivors attempting to integrate catastrophic loss into coherent self-narratives — a process that may succeed, fail, or remain deliberately suspended. Siegel’s neurobiological framing locates sense making at the intersection of hemispheric specialisation and interpersonal attunement, while Epstein’s Buddhist-psychoanalytic voice renders it an intersubjective, embodied event in which emotional experience becomes bearable through exchange. The tensions are productive: between sense making as organismic necessity and as cultural achievement, between its unconscious biological roots and its reflexive, narrative dimensions, and between the therapeutic injunction to find meaning and the clinical evidence that meaning sometimes refuses to be found.