Social disconnection occupies a pivotal position in the depth-psychology corpus, where it is understood not as mere loneliness but as a multidimensional rupture — neurobiological, relational, psychosocial, and existential simultaneously. Stephen Porges and Deb Dana ground the phenomenon in polyvagal theory, framing social disconnection as the autonomic nervous system’s shift away from ventral vagal safety into sympathetic mobilization or dorsal vagal collapse, a move driven by chronic misattunement, unrepaired ruptures, and the perception of relational danger. For Porges and Dana, disconnection is therefore less a voluntary withdrawal than a neurophysiological adaptation. Bruce Alexander’s dislocation theory broadens the frame dramatically: social disconnection is the consequence of free-market society’s systematic destruction of psychosocial integration — the balancing of individual autonomy with communal belonging — rendering entire populations vulnerable to addictive substitution. Laurence Heller situates disconnection within developmental trauma, showing how early relational failure encodes a survival strategy that dissociates the individual from body, emotion, and intimacy. Stella Dennett, drawing on Edinger and Jung, adds that the deepest form of social disconnection mirrors an intrapsychic severance between ego and Self, producing alienation neurosis. Across these voices, the corpus insists that social disconnection is simultaneously symptom, cause, and adaptive strategy — a complex that therapy must address at neurobiological, relational, and cultural levels at once.