Separation occupies a singular position across the depth-psychological corpus, appearing simultaneously as a cosmogonic act, a developmental necessity, a clinical symptom, and an alchemical operation. Edinger’s extended treatment of separatio in the alchemical tradition establishes the term’s most technically precise usage: the primal division of opposites — matter from spirit, earth from fire, soul from body — that makes consciousness possible. Here separation is not pathological but constitutive, the Logos-Cutter by which undifferentiated contents are carved from the unconscious and brought into distinct existence. Neumann and Edinger together frame the separation of the World Parents as the founding myth of ego development itself, the cosmogonic gesture that creates the space in which individual consciousness can grow. Bowlby anchors a contrasting but equally systematic treatment: separation from the attachment figure as the primal source of anxiety, grief, and psychiatric disturbance — an empirical and biological reality whose sequelae include protest, despair, and pathological mourning. Panksepp’s affective neuroscience grounds this clinical datum in brain systems mediating social bonding and distress vocalization. Winnicott mediates these poles by tracing the gradual, facilitating disillusionment that healthy separation from the mother requires. The corpus thus holds in productive tension the creative-cosmogonic and the traumatic-relational valences of the one term, a tension that gives depth psychology much of its diagnostic and mythological richness.