The self-regulating psyche stands as one of the foundational axioms of depth psychology, asserting that the psyche is not a passive recipient of external forces but an autonomous system oriented toward balance, compensation, and wholeness. Jung’s formulation of this principle holds that the unconscious produces compensatory contents—dreams, fantasies, symptoms—that counterbalance one-sided conscious attitudes, constituting what Edinger renders as a ‘trans-personal regulating process.’ This conception carries profound clinical and philosophical consequences: it repositions the therapist not as the agent of cure but as a facilitator of a process the psyche itself initiates. The corpus reveals several productive tensions around this term. Levine and Schore approach it from a neurobiological direction, mapping the emergent self-regulatory properties of the nervous system onto the psyche’s creative compensatory movement. Siegel extends the framework into relational and systems-theory territory, treating self-regulation as an integrative capacity shaped by interpersonal experience. Meanwhile, Jungian voices—Edinger, Samuels, Hall, and Quenk—insist on the suprapersonal and teleological dimensions of this regulation, linking it to individuation, the Self, and the compensatory function of the unconscious. The tension between mechanistic homeostasis and purposive psychic self-direction remains productively unresolved across the corpus.