Interoceptive Disruption designates the breakdown, distortion, or dysregulation of the processes by which the nervous system senses, interprets, and integrates signals originating within the body. Across the depth-psychology and psychophysiology corpus, no single consensus defines its precise contours, and this productive ambiguity has generated several competing orientations. Stewart and colleagues frame it primarily as a motivational deficit: disrupted interoception compels drug use as a corrective strategy against perceived internal imbalance, foregrounding negative reinforcement and withdrawal anticipation. Verdejo-Garcia distinguishes between failures of signal quality, perceptual accuracy, and appraisal, insisting that these sub-components carry distinct clinical implications and demand different interventions. Herman extends this to a feedback-loop model in which substance use both produces and is perpetuated by interoceptive deficits, while simultaneously tilting the interoception–exteroception balance toward external salience. Khalsa and the Interoception Summit 2016 position disruption within a hierarchical Bayesian framework, where attentional bias, blunted or heightened physiological sensitivity, cognitive catastrophizing, and impaired insight all constitute distinguishable failure modes. Naqvi and Bechara situate disruption anatomically in insular lesion data, demonstrating that damage to this hub can sever the conscious interoceptive representation that sustains addictive behavior. Khoury’s review of randomized controlled trials suggests that targeted interoceptive interventions can partially remediate such disruption across panic disorder, eating disorders, and substance use. The concept thus bridges neurobiological, computational, and clinical registers, making it one of the more integrative constructs in contemporary psychopathology research.