Within the depth-psychology corpus, ‘infection’ operates on at least three distinct registers, and the tension among them is generative rather than merely terminological. At the most literal level, infection appears as a medical fact — the presence of a pathogen in the body — whose causal sufficiency is, however, repeatedly called into question: Hillman, Sardello, and the traditions they invoke insist that an infectious agent is necessary but never sufficient for disease to break out, demanding that questions of meaning, host, and psychic occasion supplement the microbiological account. At a second, properly psychological register, Jung and those in his lineage — Sedgwick most systematically — deploy infection as a central metaphor for what transpires between therapist and patient: the therapist is ‘contaminated’ by the patient’s maladjustment, and this mutual psychic exposure is not an accident to be avoided but the very mechanism of healing. Here infection slides from pathology into the vocabulary of the wounded healer, and its moral valence inverts. A third register is socio-political: Jung’s writings on the mass psyche invoke ‘moral and mental infection’ as the spreading contagion of unconscious collective shadow, to which only genuine self-knowledge offers immunity. Across all three registers the corpus insists that infection is never merely biological; it is always also a question of psychic openness, resistance, and meaning.