Destruction occupies a central and irreducible position in depth-psychological thought, resisting reduction to mere pathology or negation. The corpus presents at least four distinct axes of interpretation. First, the developmental-relational axis: Winnicott argues, with characteristic precision, that the infant’s destruction of the object is the very mechanism by which the object is placed outside the self and reality constituted—destruction here is ontologically generative rather than regressive. Kalsched amplifies this Winnicottian account, tracing how survival of destruction becomes the ground of genuine object-love. Second, the archetypal-instinctual axis: Neumann locates destruction at the root of ego formation, binding it to assimilation, aggression, and the primordial act of eating; Hillman’s senex analysis maps destruction as a structural defense of petrified order, arguing that split senex consciousness issues a ‘chronic invitation to destruction.’ Third, the soul-making axis: Hillman proposes that the analytic opus—soul-making—necessarily entails soul-destroying, alchemy providing its imagery of mortification, putrefaction, and dismemberment. Fourth, the religio-ethical axis: Jung’s Red Book cautions that whoever makes destruction a goal perishes through self-destruction, while Freud frames civilization’s discontents around the war between libido and the death drive. Across all these axes, destruction is ambivalent: it founds, transforms, defends, and annihilates.