Cancer occupies a significant and contested position within the depth-psychology corpus, functioning simultaneously as a somatic fact, a psychosomatic signifier, and an existential catalyst. The literature divides broadly into three orientive stances. First, the psychosomatic tradition — represented most extensively by Gabor Maté — argues that chronic stress, emotional suppression, trauma history, and social isolation create the neuroendocrine and immunological conditions that facilitate malignant cell growth, without thereby asserting simple causal guilt. Second, the existential-therapeutic tradition — most fully elaborated by Irvin Yalom — treats a cancer diagnosis as a decisive confrontation with mortality that can paradoxically catalyze authentic living, assuming responsibility, and the dismantling of neurotic defenses. Third, Robert Sardello’s archetypal-phenomenological reading positions cancer as a spiritual symptom of modernity itself: a body attempting to materialize without soul-forming capacity, mirroring the contemporary world’s reduction of reality to mere matter. Arthur Frank adds a narrative dimension, attending to the disruption cancer wreaks upon the storied self and the repair work storytelling performs. Tensions persist between models emphasizing individual psychodynamics, cultural toxicity, and irreducible biological contingency — a tension Masters addresses by distinguishing correlation from causation in illness onset.