Brain lateralization — the differential specialization of the cerebral hemispheres — occupies a pivotal and contested position in the depth-psychology corpus. No voice commands this terrain more comprehensively than Iain McGilchrist, whose two major works treat lateralization not as a crude folk neuroscience of ‘left-brain logic versus right-brain creativity’ but as a structural account of two fundamentally different modes of attending to and constituting reality. For McGilchrist, the right hemisphere underwrites holistic, empathic, and morally inflected engagement with the world, while the left hemisphere governs instrumental, consequence-oriented, and categorically fixed cognition — distinctions with direct implications for ethics, aesthetics, and psychopathology. Allan Schore’s developmental neurobiology foregrounds the right hemisphere’s primacy in affect regulation and early relational experience, a position that Lanius and collaborators extend into trauma research, demonstrating that lateralized activation patterns — increased right-hemisphere and decreased left-hemisphere activity — are a measurable signature of traumatic memory recall and flashback phenomenology. Julian Jaynes’s bicameral mind hypothesis constitutes an earlier and more speculative intervention, linking the anterior commissure and interhemispheric transmission to the origin of auditory hallucinations and, ultimately, to the emergence of subjective consciousness. Daniel Siegel situates hemispheric asymmetry within a relational-developmental framework, emphasizing cross-hemispheric integration as the neurobiological substrate of coherent mental life. Throughout, a productive tension runs between localizationist enthusiasm and network-based caution, with McGilchrist explicitly warning against the reductive tendencies of functional neuroimaging.