redistribution of VMAT-2 (Riddle et al., 2007;
This passage identifies VMAT-2 redistribution as a direct effect of methylphenidate, positioning it alongside DAT and NET inhibition as a core mechanism of MPH action.
Vmat 2
The Seba library treats Vmat 2 in 3 passages, across 1 author (including Faraone, Stephen V.).
In the library
Administration of low-dose AMP altered VMAT-2 distribution within nerve terminals selectively in monoaminergic neurons
This passage establishes that amphetamine, even at low doses, selectively redistributes VMAT-2 within monoaminergic nerve terminals, implicating vesicular transport as a key site of psychostimulant action.
Administration of low-dose MPH altered VMAT-2 distribution within nerve termi
This passage corroborates that methylphenidate, parallel to amphetamine, produces subcellular redistribution of VMAT-2, supporting the mechanistic comparison between the two agents.
, The pharmacology of amphetamine and methylphenidate: Relevance to the neurobiology of attention-deficit/hyperactivity disorder and other psychiatric comorbidities, 2018supporting