Transduction

Transduction is therefore not merely the reasoning of the mind; it is also intuition, because it is that through which a structure appears in a domain of a problematic as providing the resolution to the problems posed

Simondon defines transduction as both a cognitive operation and an intuitive process, distinguishing it from deduction by its immanence: the resolving structure is extracted from the tensions of the problematic domain itself rather than imported from without.

Simondon, Gilbert, Individuation in Light of Notions of Form and Information, 2020thesis

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conceive in terms of transduction the processes of differentiations that are deployed starting from a metastable pre-individual system, wrought with tensions, of which the individual is one of the phases of deployment

Simondon’s editorial framing establishes transduction as the central conceptual tool for understanding how individuation unfolds from a pre-individual, metastable field of potentials and tensions.

Simondon, Gilbert, Individuation in Light of Notions of Form and Information, 2020thesis

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the relation between integration and differentiation (which can be called transduction) in the living being. In the biological being, transduction is not direct but indirect according to a twofold ascending and descending chain

Simondon extends transduction into biological theory, arguing it names the indirect, bidirectional relay between integration and differentiation in living systems, operating through chains of internal resonance rather than simple information conveyance.

Simondon, Gilbert, Individuation in Light of Notions of Form and Information, 2020thesis

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every veritable relation as having the status of being. Relation is a modality of being; it is simultaneous with respect to the terms whose existence it guarantees

This passage articulates the ontological premise that underwrites Simondon’s concept of transduction: relation itself possesses being, and thus transduction as relational operation is not merely methodological but ontological.

Simondon, Gilbert, Individuation in Light of Notions of Form and Information, 2020supporting

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very recent work on the transduction of psychosocial stress into the neurobiology of psychiatric disorders, Post (1992) outlines a model by which such stressors lead to long-lasting changes in gene expression

Schore employs ‘transduction’ in its neuroscientific sense to describe how psychosocial stress is converted into lasting neurobiological change, particularly through altered gene transcription, linking environmental experience to cellular regulation.

Schore, Allan N., Affect Regulation and the Origin of the Self: The Neurobiology of Emotional Development, 1994supporting

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These changes in signal transduction can trigger longer-term molecular neuroadaptations via transcription factors that modify gene expression.

Koob uses ‘signal transduction’ in the standard neuroscientific sense to describe how drug-induced changes in intracellular signaling cascades propagate into enduring molecular neuroadaptations relevant to addiction.

Koob, George F., Neurobiology of addiction: a neurocircuitry analysis, 2016supporting

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both signal transduction mechanisms and changes in gene transcription have been identified. For example, chronic exposure to a wide variety of abused drugs upregulates cAMP formation

Koob identifies signal transduction mechanisms as among the first molecular-level changes produced by chronic drug exposure during the binge/intoxication stage of addiction.

Koob, George F., Neurobiology of addiction: a neurocircuitry analysis, 2016supporting

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I had won the Nobel Prize in Physiology or Medicine for signal transduction in the nervous system

Kandel’s Nobel citation provides autobiographical confirmation that signal transduction in the nervous system — the biochemical conversion of extracellular messages into intracellular responses — was recognized as his foundational scientific contribution.

Kandel, Eric R., In search of memory the emergence of a new science of mind, 2006aside

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