patients are knowingly and unknowingly governed by other motives… persons who abuse substances, suffering as they do, are willing to accept such distress in exchange for whatever momentary relief they experience with their drug of choice
Khantzian argues that substance abuse is not mere physiological compulsion but a motivated, often conscious attempt to manage intolerable psychic pain, likening relapse to a compulsion to repeat unresolved developmental suffering.
, The Self-Medication Hypothesis of Substance Use Disorders: A Reconsideration and Recent Applications, 1997thesis