Significance occupies a remarkably plural position within the depth-psychology corpus, functioning simultaneously as an existential category, a religious-psychological motivation, an aesthetic criterion, and a technical marker within semiological theory. Pargament constructs it as the primary telos of human coping: people are volitional beings who organize their entire spiritual and psychological lives around objects of significance, conserving, reconstructing, and—under extreme pressure—transforming what they hold most dear. For Pargament, religion defines itself precisely as the sacred’s intersection with this search. Rudhyar, reading through an astrological-depth lens, situates significance as an emergent property arising from the individual’s interpretive encounter with collective substance: significance is ontologically ubiquitous but perceptually contingent, and its absence indexes not the world’s poverty but the perceiver’s limitation. Benveniste, approaching from structural linguistics, introduces signifiance as the general condition of meaningfulness inhering in language’s two-leveled functioning—a technical counterpart to the psychological notion. Chambless invokes the clinical distinction between statistical and clinical significance, insisting that therapeutic value requires both. Across these voices a persistent tension emerges: is significance discovered in the world, constituted by the organism, or conferred through symbolic and religious practice? That tension—between immanent teleology and projected meaning, between measurable effect and lived mattering—defines the term’s productive instability throughout the library.