Psychic infection occupies a distinctive position in the depth-psychology corpus as both a clinical metaphor and a socio-cultural diagnostic. Jung introduced the term with deliberate epidemiological force: the therapist, like any organism exposed to pathogenic material, does not remain untouched by the patient’s psychological disorder. In Sedgwick’s careful unpacking, this metaphor shifts registers—from medical contagion toward a more fully psychological account of mutual vulnerability, emotional hurt, and the porous boundary between healer and sufferer. At the clinical level, psychic infection names what happens in the consulting room when the analyst’s own unconscious is mobilized by contact with pathology; it underlies the Jungian insistence on the analyst’s personal analysis as prophylactic and as preparation. At the collective level, Jung deploys a cognate concept—the psychic epidemic—to account for political possession, mass irrationality, and the spread of ideological fanaticism when rational checks fail and the threshold of affect is breached. The index entry in Civilization in Transition explicitly equates ‘infection: psychic’ with ‘epidemic, psychic,’ confirming the terminological continuity. Sedgwick, the primary commentator represented here, traces the metaphor’s limits with precision, noting that no literal microbes are involved and that the concept most productively serves as a bridge to notions of countertransference and the wounded healer. The concept thus stands at the intersection of clinical technique, analytical ethics, and cultural pathology.