Psychedelic therapy occupies a position of singular methodological and philosophical importance within the depth-psychology corpus, functioning simultaneously as clinical practice, epistemological challenge, and cartographic instrument for mapping the unconscious. The literature divides, with notable precision, between two principal modalities: the psycholytic approach, favored by European practitioners, which employs repeated low-to-medium doses of LSD in the context of conventional analytic work; and the psychedelic approach, characteristic of North American practice, which utilizes high-dose, single or infrequent sessions aimed at inducing peak or transcendental states. Grof stands as the corpus’s dominant voice, arguing from decades of clinical observation that the psychedelic procedure is not merely an accelerant of existing analytic techniques but a catalyst for experiences — perinatal and transpersonal — that fall entirely outside the Freudian conceptual map, thereby demanding a radical revision of the model of the human psyche. Mahr and Sweigart extend this argument into explicitly Jungian territory, contending that psychedelic states provide privileged access to archetypal material. Carhart-Harris grounds therapeutic efficacy in neurodynamic theory, while Strassman and Clayton register the necessity of integrating spiritual, ethical, and trauma-sensitive frameworks into the therapist’s preparation. A persistent tension runs through the corpus: whether psychedelic-induced transformations represent genuine structural change or merely temporary affective reorganization.