The term ‘Psyche Seeking’ occupies a contested but generative space within the depth-psychology corpus, spanning neurobiological substrate, mythological narrative, and clinical phenomenology. At its most foundational, the concept designates the psyche’s constitutive drive toward engagement, meaning, and reunion — what Panksepp names the SEEKING system, a genetically prewired mesolimbic circuit that generates appetitive arousal, exploratory locomotion, and anticipatory states. This neuroscientific formulation finds its symbolic counterpart in the Apuleian myth of Psyche and Eros, wherein Kalsched reads the soul’s compelled illumination of the hidden beloved as a paradigmatic enactment of psychic seeking: desire overcoming prohibition, consciousness risking annihilation for contact with the numinous. Hollis extends the motif into the clinical middle passage, where the psyche’s seeking of neglected functions and unlived life constitutes the essential agenda of individuation. Alcaro and Carta bridge the neuro-ethological and analytic registers, proposing that the SEEKING disposition — rooted in the mesolimbic dopaminergic system — underlies imagination itself, including self-projective temporal exploration. A persistent tension in the literature concerns whether seeking culminates in possession of its object or whether the condition of seeking is itself the telos: Panksepp’s observation that pleasure emerges from the cessation of SEEKING arousal implies that the psyche most intensely lives in the interval before attainment.