Prefrontal Cortical Compromise designates the cluster of deficits — in reasoning, decision-making, affect regulation, planning, and social judgment — that follow structural or functional impairment of prefrontal cortical regions. Within the depth-psychology corpus, the term anchors a sustained argument that rationality is not separable from emotion: damage to the ventromedial prefrontal cortex, as Damasio demonstrates through the cases of Phineas Gage and the patient Elliot, produces precisely this dissociation, stripping subjects of somatic guidance while leaving verbal intelligence largely intact. Schore extends the developmental register, showing that early dyadic failure during critical periods impairs the structural maturation of orbitofrontal circuits, producing enduring deficits in affect autoregulation. Maté situates the prefrontal cortex as the brain’s executive officer whose chronic compromise underlies addictive vulnerability. Lewis adds a developmental arc, tracing how dorsolateral prefrontal maturation — completing only in the early twenties — governs the higher echelons of self-control. Flores brings a clinical-forensic perspective, noting that alcoholic patients present prefrontal-lesion-like profiles — perseveration, abstraction failure, motivational impairment — that render standard treatment largely ineffective. Across these voices, prefrontal cortical compromise functions as the neurobiological hinge between intrapsychic deficits and relational pathology, making it indispensable for any depth-psychological account of character, affect regulation, or addictive process.