Within the depth-psychology corpus and its allied classical scholarship, ‘plague’ functions as far more than an epidemiological datum: it operates as a dense symbolic node linking divine wrath, collective transgression, psychological pollution, and the porous boundary between soma and psyche. The richest treatments cluster around Homer’s Iliad, where Apollo’s plague upon the Achaeans—unleashed by Agamemnon’s dishonoring of the priest Chryses—establishes the archetypal grammar: civic impiety summons divine retribution that manifests as bodily catastrophe. Padel traces how Greek tragic and medical thought renders plague a figure for passion, moral corruption, and anomia simultaneously, while Rohde and Burkert illuminate the ritual economy of expiation—the pharmakos, the hero-cult, the oracle—through which plague becomes the engine of purificatory religion. Sardello reads the medieval plague as the return of a dissociated earth-connection, giving the motif a distinctly archetypal-ecological inflection. Giegerich deploys plague as an epistemological analogy: explaining psychological disorder at the wrong level of description, as medievals explained plague by sin rather than microorganism. Together these voices reveal plague as a compressed symbol of the relationship between collective hubris, invisible causation, sacrificial remedy, and the collapse of the boundary between inner disorder and outer catastrophe—a symbol whose psychological productivity the corpus consistently exceeds its merely historical register.