The Neurotransmitter Framework, as it appears across the depth-psychology and affective-neuroscience corpus assembled in this library, designates the theoretical architecture by which scholars map chemical signaling agents — dopamine, serotonin, norepinephrine, acetylcholine, GABA, glutamate, and the neuropeptides — onto psychological states, motivational circuits, and pathological conditions. The framework is not monolithic. Panksepp deploys it as the neurochemical backbone of primary emotional systems, organizing transmitter classes into functional categories that interface directly with behavioral prediction. Kandel approaches it from a molecular-biological vantage, tracing how transmitter release cascades into second-messenger signaling, synaptic plasticity, and ultimately memory formation. In the addiction literature, Koob, Blum, and Maté converge on dopaminergic reward circuitry as the fulcrum of compulsive behavior, while Garland extends this into a neurocognitive model where adaptive versus maladaptive transmitter dynamics determine the trajectory of craving and recovery. Schore integrates the framework developmentally, arguing that early dyadic experience sculpts catecholaminergic circuits in ways that govern lifelong affect regulation. The central tension throughout is reductionist specificity versus systemic complexity: single-transmitter accounts of emotion or pathology are repeatedly challenged by evidence of cascading, multi-system interactions that resist clean causal attribution.