Leprosy occupies a significant symbolic register within the depth-psychology corpus, functioning primarily as a metaphor for corruption, spiritual contamination, and the necessity of purification rather than as a clinical subject. The term migrates across several distinct discursive fields. In the alchemical literature studied by Jung, von Franz, Hillman, Edinger, and Abraham, leprosy denotes the corrupted, impure state of base metals prior to their transmutation—the ‘leprosy of metals’ figures the nigredo condition from which the opus must redeem matter toward gold. Hillman extends this into a subtle phenomenology of silver’s phlegmatic indolence, reading ‘leprosy’ as the necessary, even dignified companion of intellectual life. In biblical and theological frameworks—drawn on by Kurtz, the Philokalia translators, and the Aurora Consurgens commentary of von Franz—leprosy figures sin’s social contagion, its alienating power, and the divine prerogative of cure (Naaman’s healing in the Jordan as prefiguration of baptism). Hillman’s aside on ‘phlegmatic leprosy’ and Edinger’s invocation of the ‘leprosy of metals’ as the alchemical benedicta viriditas reveal a productive tension: what appears as morbid corruption harbors latent vitality. Schaberg records the term used colloquially in early AA texts as hyperbolic avoidance. The passages collectively reveal how leprosy anchors discussions of impurity, transformation, and healing across religious, alchemical, and cultural registers.