The I-Thou relation, drawn from Martin Buber’s foundational 1922 text I and Thou, enters the depth-psychology corpus primarily as a normative horizon against which analytic encounter, transference, and authentic selfhood are measured. Yalom deploys it to anchor his existential-isolation framework, arguing that the I-Thou is the quintessential relational buttress against the terror of aloneness — a mutuality so radical that the very ‘I’ is reconstituted within the encounter rather than pre-existing it. Jacoby, writing from within Analytical Psychology, submits Buber’s categories to the most sustained clinical scrutiny: he presses the distinction between I-Thou and I-It as a lens on projection, countertransference, and the analyst’s obligation of honesty, while also registering the tension between Buber’s ‘primary’ I-Thou and Jung’s concept of participation mystique, noting that undifferentiated merger and genuine otherness are not equivalent. Flores recruits the Buberian ‘sphere of between’ to theorize what is missing in addictive relatedness, linking denial-of-need to the foreclosure of genuine dialogue. Across these voices a central tension persists: whether I-Thou encounter is an achievable therapeutic goal or an eschatological ideal that clinical reality can only asymptotically approach. The term consequently functions simultaneously as clinical criterion, ontological claim about the constitution of selfhood, and ethical imperative within the therapeutic dyad.