Existential anxiety occupies a pivotal position within depth psychology, marking the point at which philosophical ontology and clinical practice converge. Unlike neurotic anxiety, which is bound to particular objects or histories, existential anxiety arises from the individual’s direct confrontation with what Yalom designates the ‘ultimate concerns’: death, freedom, isolation, and meaninglessness. Yalom’s Existential Psychotherapy (1980) remains the most systematic clinical elaboration of the concept, tracing how raw existential anxiety is relentlessly transformed into neurotic symptomatology through denial-based defenses, and arguing that psychopathology is, at its core, an ineffective strategy for managing this primal dread. Heidegger’s Being and Time furnishes the ontological scaffold: anxiety discloses Dasein’s thrownness and uncanniness, arising not from any determinate entity but from the groundlessness of Being-in-the-world itself. LeDoux offers a neuroscientific counterpoint, noting that existential anxieties — worries about mortality and meaning — are not reducible to survival-circuit activation, thus preserving their distinctively cognitive-interpretive character. Simondon approaches anxiety as a liminal phenomenon that exceeds both feeling and emotion, indexing the tension within individuation itself. Welwood situates existential anxiety within a Buddhist-psychotherapeutic synthesis, treating its emergence as an invitation toward genuine presence rather than an affliction to be suppressed. The corpus thus reveals a productive tension: whether existential anxiety is the engine of pathology, the gateway to authenticity, or the mark of individuation’s incompleteness.