The concept of epistemological crisis occupies a peculiar and revealing position within the depth-psychology corpus, functioning simultaneously as a clinical phenomenon, a civilizational diagnosis, and a heuristic for psychological transformation. Its most precise formulation arrives through Gregory Bateson’s commentary on Jung’s composition of the Septem Sermones ad Mortuos, wherein Bateson identifies Jung’s pre-creative psychotic episode as an instance of epistemological confusion made productive: when the knowing-structure collapses, pathological dissociation may ensue, but the recovery of ordered differentiation — in Jung’s case, the distinction between pleroma and creatura — restores psychological coherence. This individual-level crisis mirrors, for Tarnas, a civilizational predicament: modernity’s epistemological strategies, forged in Enlightenment rationalism and empiricism, have systematically evacuated meaning from the cosmos while constructing a subject increasingly alienated from its world. McGilchrist frames related terrain through hemispheric asymmetry, contending that left-hemisphere dominance generates a ‘sustained incoherence’ in which our dominant model of reality is demonstrably mistaken. Papadopoulos traces the crisis into Jung’s own ambivalence about acknowledging his epistemological contributions, noting that Jung both possessed sophisticated epistemological commitments and was reluctant to foreground them. Across these voices the term gathers density: epistemological crisis is not merely intellectual confusion but a psychospiritual rupture in the relationship between the knower, the known, and the cosmos that sustains both.