The loss of self, says Kierkegaard, is ‘sickness unto death’; it is despair—despair at not being conscious of having a self, or despair at not being willing to be ourselves.
Horney, via Kierkegaard, identifies despair as the defining affect of self-alienation — a silent, clinically overlooked condition in which the individual has lost contact with the core of psychic existence.
, Neurosis and Human Growth: The Struggle Toward Self-Realization, 1950thesis