The concept of cause occupies a contested and generative position across the depth-psychology corpus, where it functions simultaneously as a epistemological premise, a metaphysical category, and a practical tool for understanding psychic life. The corpus reveals three broad axes of engagement. First, the classical philosophical lineage—Aristotle’s fourfold causality (material, formal, efficient, final), Stoic determinism and fate, Plotinus on self-caused being, and Descartes on efficient and formal causation—furnishes the conceptual vocabulary that depth psychology inherits and sometimes transforms. Second, Jung and those working in his tradition (Edinger, von Franz, Stein) engage cause primarily through the lens of synchronicity: the claim that psychic events may be meaningfully co-incident without standing in any causal relation, which places the principle of causality itself under critical scrutiny. Von Franz in particular traces the theological genealogy of causal determinism back to Descartes’s image of a God who binds himself to his own laws, contrasting this with the acausal creativity she locates in synchronistic phenomena. Third, thinkers such as McGilchrist probe the limits of isolating discrete causal factors from the continuous flow of becoming, asking whether causation as ordinarily conceived falsifies the holistic character of reality. The term thus stands at a crossroads between mechanistic determinism, Aristotelian teleology, Jungian synchronicity, and the question of psychic freedom.