Alienation occupies a pivotal position across the depth-psychological corpus, functioning simultaneously as a clinical descriptor, a metaphysical condition, and a cultural diagnosis. Edinger anchors its intrapsychic meaning most precisely: alienation names the rupture of the ego-Self axis, wherein the developing ego, severed from the numinous ground of the Self through inadequate parental mirroring, acquires a wound that predisposes it to states of despair, violence, and meaninglessness. Horney extends the concept inward as ‘alienation from self’—the neurotic’s dissociation from spontaneous feeling, authentic wish, and genuine agency, a condition she traces from Kierkegaard’s ‘sickness unto death’ through to clinical phenomena ranging from fog-states and depersonalization to chameleon-like role-playing. Fromm situates alienation historically and socially, reading it as the price exacted by the individuating self’s emergence from primary bonds and by capitalism’s reduction of persons to market values. Abrams documents its literary and philosophical genealogy—the Romantic and post-Romantic tradition of the ‘alienated hero’ in a disintegrated cosmos. McGilchrist maps its phenomenological correlate in the schizophrenic’s experience of ‘thingness,’ where objectification and alienation reciprocally intensify one another. Campbell reads it as the mythological Waste Land produced by the collapse of living symbol-systems. Hoeller identifies the alienated ego with the Gnostic demiurge—blind to its own unconscious roots. Together these voices reveal alienation as the master pathology of modernity, demanding both psychological repair and symbolic renewal.