Alcohol occupies a multivalent position across the depth-psychology corpus, functioning simultaneously as a psychosexual symbol, a neurobiological agent, a social pathogen, and a clinical challenge demanding pharmacological management. Karl Abraham’s early psychoanalytic contribution frames alcohol as a mediator of repressed sexuality and masculine identity, tracing the differential relation of men and women to intoxication through the vicissitudes of libidinal economy and sublimation. Later voices, notably Addenbrooke drawing on Jungian clinical tradition, situate alcohol addiction within a broader psychology of addiction as defence against psychic pain, shadow identification, and the arrested development of the self. The neuroscientific strand—represented by Lovelock’s interoceptive framework—reframes alcohol’s hold on the organism through GABA, NMDA, and serotonergic receptor dynamics, insular cortex remodelling, and the disruption of body-state signalling that underlies craving and relapse. McPheeters and Antonelli represent the pharmacotherapy horizon, surveying naltrexone, acamprosate, baclofen, and topiramate as chemical responses to alcohol use disorder, now codified by DSM-5-TR criteria. Alexander and Hari contest the reductive disease model, embedding alcohol misuse in social dislocation and the iron law of prohibition. The corpus thus presents alcohol as a site of irreducible tension between intrapsychic, neurobiological, sociocultural, and clinical-pharmacological accounts.